Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Endocrinol Metab. 2012 Jan;97(1):132-7. doi: 10.1210/jc.2011-2107. Epub 2011 Oct 26.

Aortic valve calcification in mild primary hyperparathyroidism.

Author information

1
Department of Medicine, Columbia University, New York, New York 10032, USA.

Abstract

CONTEXT:

It is unclear whether cardiovascular disease is present in primary hyperparathyroidism (PHPT).

OBJECTIVE:

Aortic valve structure and function were compared in PHPT patients and population-based controls.

DESIGN:

This is a case-control study.

SETTING:

The study was conducted in a university hospital metabolic bone disease unit.

PARTICIPANTS:

We studied 51 patients with PHPT and 49 controls.

OUTCOME MEASURES:

We measured the aortic valve calcification area and the transaortic pressure gradient.

RESULTS:

Aortic valve calcification area was significantly higher in PHPT (0.24 ± 0.02 vs. 0.17 ± 0.02 cm(2), p<0.01), although there was no difference in the peak transaortic pressure gradient, a functional measure of valvular calcification (5.6 ± 0.3 vs. 6.0 ± 0.3 mm Hg, P = 0.39). Aortic valve calcification area was positively associated with PTH (r = 0.34; P < 0.05) but not with serum calcium, phosphorus, or 25-hydroxyvitamin D levels or with calcium-phosphate product. Serum PTH level remained an independent predictor of aortic valve calcification area after adjustment for age, sex, body mass index, smoking status, history of hypercholesterolemia and hypertension, and estimated glomerular filtration rate.

CONCLUSIONS:

Mild PHPT is associated with subclinical aortic valve calcification. PTH, but not serum calcium concentration, predicted aortic valve calcification. PTH was a more important predictor of aortic valve calcification than well-accepted cardiovascular risk factors.

PMID:
22031523
PMCID:
PMC3251929
DOI:
10.1210/jc.2011-2107
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for PubMed Central
    Loading ...
    Support Center