Format

Send to

Choose Destination
See comment in PubMed Commons below
Organogenesis. 2011 Jul-Sep;7(3):209-16. doi: 10.4161/org.7.3.18462. Epub 2011 Jul 1.

Planar polarity: A new player in both lung development and disease.

Author information

1
Peter MacCallum Cancer Institute, Melbourne, Australia.

Abstract

The clinical burden of both adult and neonatal lung disease worldwide is substantial; in the UK alone, respiratory disease kills one in four people. It is increasingly recognized that genes and pathways that regulate lung development, may be aberrantly activated in disease and/or reactivated as part of the lungs' intrinsic repair mechanisms. Investigating the genes and signaling pathways that regulate lung growth has led to significant insights into the pathogenesis of congenital and adult lung disease. Recently, the planar cell polarity (PCP) pathway has been shown to be required for normal lung development, and data suggests that this signaling pathway is also involved in the pathogenesis of some lung diseases. In this review, we summarize current evidence indicating that the PCP pathway is required for both lung development and disease.

PMID:
22030785
PMCID:
PMC3243034
DOI:
10.4161/org.7.3.18462
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center