Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Cycle. 2011 Oct 15;10(20):3466-72. doi: 10.4161/cc.10.20.17764. Epub 2011 Oct 15.

Endocrine pancreas development in zebrafish.

Author information

1
University of California, Los Angeles, Los Angeles, CA, USA.

Abstract

Type 1 diabetes results from the autoimmune destruction of insulin-producing pancreatic β cells. Current efforts to cure diabetes are aimed at replenishing damaged cells by generating a new supply of β cells in vitro. The most promising strategy for achieving this goal is to differentiate embryonic stem (ES) cells by sequentially exposing them to signaling molecules that they would normally encounter in vivo. This approach requires a thorough understanding of the temporal sequence of the signaling events underlying pancreatic β-cell induction during embryonic development. The zebrafish system has emerged as a powerful tool in the study of pancreas development. In this review, we provide a temporal summary of pancreas development in zebrafish with a special focus on the formation of pancreatic β cells.

PMID:
22030554
DOI:
10.4161/cc.10.20.17764
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center