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Curr Opin Microbiol. 2012 Feb;15(1):108-14. doi: 10.1016/j.mib.2011.10.002. Epub 2011 Oct 24.

Salmonella, the host and its microbiota.

Author information

1
Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA, United States.

Abstract

The intestine is host to a diverse bacterial community whose structure, at the phylum level, is maintained through unknown mechanisms. Acute inflammation triggered by enteric pathogens, such as Salmonella enterica serotype Typhimurium (S. Typhimurium), is accompanied by changes in the bacterial community structure marked by an outgrowth of the pathogen. Recent studies show that S. Typhimurium can harness benefit from the host response to edge out the beneficial bacterial species that dominate in the healthy gut. The elucidation of how S. Typhimurium alters the bacterial community structure during gastroenteritis is beginning to provide insights into mechanisms that dictate the balance between the host and its microbiota.

PMID:
22030447
PMCID:
PMC3265626
DOI:
10.1016/j.mib.2011.10.002
[Indexed for MEDLINE]
Free PMC Article

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