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Appl Physiol Nutr Metab. 2011 Dec;36(6):1009-13. doi: 10.1139/h11-098. Epub 2011 Oct 27.

Gender differences in the effects of methylphenidate on energy intake in young adults: a preliminary study.

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Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada.


The present study examined gender differences in response to methylphenidate (MPH) on energy intake and macronutrient preference. Twelve adults (6 men, 6 women) were given placebo or short-acting MPH (0.5 mg/kg) in a randomized, double blind, placebo-controlled crossover fashion. One hour after drug administration, appetite sensations and the relative reinforcing value of energy-dense snack food were measured, followed immediately by energy intake and macronutrient preference during a buffet lunch. Relative to placebo, men exhibited a significantly greater reduction in energy intake, fat intake, and carbohydrate intake after MPH administration compared with women. Future research is needed to verify these initial findings.

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