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Indian J Endocrinol Metab. 2011 Oct;15(4):337-40. doi: 10.4103/2230-8210.85598.

Adult onset pseudohypoparathyroidism type-1b with normal phosphaturic response to exogenous parathyroid hormone.

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1
Department of Endocrinology, Army Hospital (Research and Referral), Delhi Cantt, India.

Abstract

Pseudohypoparathyroidism type-1b is a hereditary disorder of clinical hypoparathyroidism without AHO phenotype, characterized by blunted nephrogenous cyclic-AMP (cAMP) response to exogenous parathyroid hormone (PTH). Here we report a young adult presenting with hypocalcemic tetany with raised PTH levels. His urinary cAMP response to exogenous PTH (recombinant 1-34) was blunted; however, phosphaturic response was normal.

KEYWORDS:

Parathyroid hormone; pseudohypoparathyroidism; urinary cyclic-AMP

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