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Clin Dev Immunol. 2012;2012:983203. doi: 10.1155/2012/983203. Epub 2011 Oct 19.

Inflammation as an animal development phenomenon.

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Department of Pharmacology, Biological Sciences Centre, Federal University of Santa Catarina, 88049-900 Florianópolis, SC, Brazil.


Inflammation is a term that has been used throughout history in different contexts; it may represent a simple collection of clinical symptoms for which drugs are developed, a disease mechanism, or even a defense mechanism against microbes validating Pasteur's studies on bacteriology and Darwin's proposed struggle for survival. Thus, an explanation of this term must also consider the scientific questions addressed. In this study, I propose that several of the inflammatory events typically described in immunological, pathological, and pharmacological contexts can also be perceived as mechanisms of animal development. Thus, by recognizing that the generation of an animal form, its conservation, and its regeneration after tissue damage are phenomena of the same nature, inflammation can be addressed through the approach of developmental biology, thereby acquiring a much neglected physiological counterpart.

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