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J Indian Soc Periodontol. 2011 Jul;15(3):190-8. doi: 10.4103/0972-124X.85659.

Osteoimmunology - Unleashing the concepts.

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Department of Periodontics, Army College of Dental Sciences, Secunderabad, Andhra Pradesh, India.


Osteoimmunology is an emerging field of research dedicated to the relationship between the immune processes and the bone metabolism of various inflammatory bone diseases. The regulatory mechanisms governing the osteoclast and osteoblast are critical for understanding the health and disease of the skeletal system. These interactions are either by cell to cell contact or by the secretion of immune regulatory mediators like cytokines and chemokines by immune cells that are governed by the RANKL (TRANCE)-RANK- OPG axis. TRANCE-RANK signaling has served as a cornerstone of osteoimmunology research. There is increased recognition of the importance of the inflammatory and immune responses in the pathogenesis of periodontal disease. Thus, this field has provided a framework for studying the mechanisms underlying periodontal destruction. As bone homeostasis is mainly regulated by both the immune and endocrine systems, there emerged osteoimmunoendocrinology where adipokines take the lead. This review focuses on the underlying concepts of osteoimmunology, its relation to Periodontics.


Bone; TRANCE; immune system; inflammation; osteoclastogenesis; osteoimmunology; resorption

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