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Yonsei Med J. 2011 Nov;52(6):953-60. doi: 10.3349/ymj.2011.52.6.953.

The association of SERPINE2 gene with COPD in a Chinese Han population.

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1
Department Respiratory, Qilu Hospital of Shandong University, Jinan, China.

Abstract

PURPOSE:

Polymorphisms of several candidate genes have been studied and associated with the development of chronic obstructive pulmonary disease (COPD). One such candidate is the SERPINE2 (Serpin peptidase inhibitor, clade E member 2) gene.

MATERIALS AND METHODS:

To assess whether the SERPINE2 gene is associated with COPD in a Chinese Han population. Samples were collected from a Chinese Han population and analyzed for the association of single nucleotide polymor phisms (SNPs) or haplotypes of SERPINE2 gene with COPD in a case-control study. Three SNPs including rs840088 G/A in intron 1, rs1438831 A/G in 5' upstream sequence and rs3795879 G/A in intron 3 were detected using the polymerase chain reaction (PCR)-based restriction fragment length polymorphism technique in 409 COPD subjects and 411 controls. Genotyping of the SREPINE2 polymorphisms at positions rs840088, rs1438831and rs3795879 was performed.

RESULTS:

We found that none of the rs840088G/A, rs1438831G/A and rs3795879 G/A polymorphisms were associated with the disease. The p-values were 0.630, 0.208 and 0.398 respectively.

CONCLUSION:

Our data suggested that there was no significant association between SERPINE2 polymorphism and COPD susceptibility in the Chinese Han population.

PMID:
22028159
PMCID:
PMC3220248
DOI:
10.3349/ymj.2011.52.6.953
[Indexed for MEDLINE]
Free PMC Article
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