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Semin Cell Dev Biol. 2011 Dec;22(9):946-52. doi: 10.1016/j.semcdb.2011.09.016. Epub 2011 Oct 19.

The CCAN complex: linking centromere specification to control of kinetochore-microtubule dynamics.

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1
Centre for Mechanochemical Cell Biology, Warwick Medical School, University of Warwick, Coventry, UK. andrew@mechanochemistry.org

Abstract

For over 70 years, chromosomes have been known to oscillate back-and-forth on the metaphase plate. These movements are directed by kinetochores, the microtubule-attachment complexes on centromeres that regulate the dynamics of bound spindle microtubules. Recent evidence shows that the CCAN (Constitutive Centromere Associated Network) kinetochore network, which directly binds centromeric nucleosomes, plays a crucial role in the control of kinetochore microtubule dynamics. Here we review how this 15-subunit protein network functions within the kinetochore machinery, how it may adapt dynamically both in time and in space to the functional requirements necessary for controlled and faithful chromosome movements during cell division, and how this conserved protein network may have evolved in organisms with different cell division machineries.

PMID:
22027615
DOI:
10.1016/j.semcdb.2011.09.016
[Indexed for MEDLINE]
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