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J Pediatr Gastroenterol Nutr. 2012 Apr;54(4):446-53. doi: 10.1097/MPG.0b013e31823d34c3.

Brain-gut axis: from basic understanding to treatment of IBS and related disorders.

Author information

1
Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. camilleri.michael@mayo.edu

Abstract

The present review describes advances in understanding the mechanisms and provide an update of present and promising therapy directed at the gut or the brain in the treatment of irritable bowel syndrome (IBS). The diagnosis of IBS typically is based on identification of symptoms, such as the Rome III criteria for IBS in adults and children. The criteria are similar in children and adults. The focus of the present review is the bowel dysfunction associated with IBS.

PMID:
22027566
PMCID:
PMC3294167
DOI:
10.1097/MPG.0b013e31823d34c3
[Indexed for MEDLINE]
Free PMC Article

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