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J Biosci Bioeng. 2012 Jan;113(1):26-9. doi: 10.1016/j.jbiosc.2011.09.007. Epub 2011 Oct 24.

Display of the antigenic region of Nipah virus nucleocapsid protein on hepatitis B virus capsid.

Author information

1
Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Abstract

The C-terminal domain of Nipah virus (NiV) nucleocapsid protein (NP₄₀₁₋₅₃₂) was inserted at the N-terminus and the immunodominant loop of hepatitis B core antigen (HBc). The stability of NP₄₀₁₋₅₃₂ increased tremendously when displayed on the HBc particles. These particles reacted specifically with the swine anti-NiV and the human anti-HBc antisera.

PMID:
22024533
DOI:
10.1016/j.jbiosc.2011.09.007
[Indexed for MEDLINE]

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