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Mol Cell Proteomics. 2012 Feb;11(2):M111.010645. doi: 10.1074/mcp.M111.010645. Epub 2011 Oct 24.

Quantitative proteomics reveals new insights into erythrocyte invasion by Plasmodium falciparum.

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1
School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.

Abstract

Differential expression of ligands in the human malaria parasite Plasmodium falciparum enables it to recognize different receptors on the erythrocyte surface, thereby providing alternative invasion pathways. Switching of invasion from using sialated to nonsialated erythrocyte receptors has been linked to the transcriptional activation of a single parasite ligand. We have used quantitative proteomics to show that in addition to this single known change, there are a significant number of changes in the expression of merozoite proteins that are regulated independent of transcription during invasion pathway switching. These results demonstrate a so far unrecognized mechanism by which the malaria parasite is able to adapt to variations in the host cell environment by post-transcriptional regulation.

PMID:
22023809
PMCID:
PMC3277754
DOI:
10.1074/mcp.M111.010645
[Indexed for MEDLINE]
Free PMC Article
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