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PLoS One. 2011;6(10):e26164. doi: 10.1371/journal.pone.0026164. Epub 2011 Oct 12.

SMN requirement for synaptic vesicle, active zone and microtubule postnatal organization in motor nerve terminals.

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1
Department of Medical Physiology and Biophysics, School of Medicine, University of Seville, Seville, Spain.

Abstract

Low levels of the Survival Motor Neuron (SMN) protein produce Spinal Muscular Atrophy (SMA), a severe monogenetic disease in infants characterized by muscle weakness and impaired synaptic transmission. We report here severe structural and functional alterations in the organization of the organelles and the cytoskeleton of motor nerve terminals in a mouse model of SMA. The decrease in SMN levels resulted in the clustering of synaptic vesicles (SVs) and Active Zones (AZs), reduction in the size of the readily releasable pool (RRP), and the recycling pool (RP) of synaptic vesicles, a decrease in active mitochondria and limiting of neurofilament and microtubule maturation. We propose that SMN is essential for the normal postnatal maturation of motor nerve terminals and that SMN deficiency disrupts the presynaptic organization leading to neurodegeneration.

PMID:
22022549
PMCID:
PMC3192162
DOI:
10.1371/journal.pone.0026164
[Indexed for MEDLINE]
Free PMC Article
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