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PLoS One. 2011;6(10):e25445. doi: 10.1371/journal.pone.0025445. Epub 2011 Oct 14.

attract: A method for identifying core pathways that define cellular phenotypes.

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1
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America. jess@jimmy.harvard.edu

Abstract

attract is a knowledge-driven analytical approach for identifying and annotating the gene-sets that best discriminate between cell phenotypes. attract finds distinguishing patterns within pathways, decomposes pathways into meta-genes representative of these patterns, and then generates synexpression groups of highly correlated genes from the entire transcriptome dataset. attract can be applied to a wide range of biological systems and is freely available as a Bioconductor package and has been incorporated into the MeV software system.

PMID:
22022396
PMCID:
PMC3194807
DOI:
10.1371/journal.pone.0025445
[Indexed for MEDLINE]
Free PMC Article
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