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Biomol Concepts. 2011 Oct 1;2(5):365-377.

Structures and Mechanism of the Monoamine Oxidase Family.

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Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229.


Members of the monoamine oxidase family of flavoproteins catalyze the oxidation of primary and secondary amines, polyamines, amino acids, and methylated lysine side chains in proteins. The enzymes have similar overall structures, with conserved FAD-binding domains and varied substrate-binding sites. Multiple mechanisms have been proposed for the catalytic reactions of these enzymes. The present review compares the structures of different members of the family and the various mechanistic proposals.

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