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Indian J Pharmacol. 2011 Sep;43(5):516-9. doi: 10.4103/0253-7613.84957.

Cardioprotective effect of fenugreek on isoproterenol-induced myocardial infarction in rats.

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1
Department of Biochemistry, Periyar University, Salem - 636 011, Tamil Nadu, India.

Abstract

OBJECTIVES:

This study is designed to evaluate the cardioprotective effect of fenugreek on isoproterenol- induced myocardial infarction and is investigated by an in vivo method in rats.

MATERIALS AND METHODS:

Male Wistar albino rats were divided into four groups (n=10). Group I received 0.5% CMC treated as normal control group. Group II received isoproterenol (85 mg/kg body weight) intraperitoneal (i.p.) for two consecutive days (14(th) and 15(th) days). Group III received fenugreek (250 mg/kg body weight) intragastric intubation for 15 days. Group IV rats received fenugreek as in Group III and additionally isoproterenol was given for two consecutive days (14(th) and 15(th) days).

RESULTS:

The results described the cardioprotective effect that observed in Group IV showed significantly (P< 0.05) decreased levels of TBARS and enhanced the activities of both enzymatic and non-enzymatic antioxidants (SOD, CAT, GPx and GSH) in myocardial infarcted rats when compared to Groups II and III. Histopathological studies were also co-relating with the above biochemical parameters.

CONCLUSION:

These findings concluded the cardioprotective effect of fenugreek on lipid peroxidation and antioxidant defense system during isoproterenol-induced myocardial infarction in rats.

KEYWORDS:

Antioxidants; fenugreek; isoproterenol; myocardial infarction

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