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Int J Hematol. 2011 Nov;94(5):491-4. doi: 10.1007/s12185-011-0952-2. Epub 2011 Oct 22.

Successful treatment of mast cell sarcoma of the uterus with imatinib.

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1
Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Abstract

Mast cell sarcoma is a rare disease characterized by localized, but destructive and rapid, growth of the tumor, high risk of distant metastasis, possibility of a leukemic phase, and poor prognosis. We report successful treatment of uterine mast cell sarcoma with imatinib in a 39-year-old woman who presented with abdominal distention and massive ascites. Routine treatment, such as combined chemotherapy, had little effect. We administered imatinib to the patient and achieved a good response in the absence of c-kit mutation, BCR/ABL, and FIP1L1-PDGFRα. Our results indicate that imatinib is of potential use in the treatment of mast cell sarcoma.

PMID:
22020400
DOI:
10.1007/s12185-011-0952-2
[Indexed for MEDLINE]
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