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Nat Struct Mol Biol. 2011 Oct 23;18(11):1300-2. doi: 10.1038/nsmb.2140.

Messenger RNA interactions in the decoding center control the rate of translocation.

Author information

1
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.

Abstract

During protein synthesis, mRNA and tRNAs are iteratively translocated by the ribosome. Precisely what molecular event is rate limiting for translocation is not known. Here we show that disruption of the interactions between the A-site codon and the ribosome accelerates translocation, suggesting that the release of the mRNA from the decoding center of the ribosome is the rate-limiting step of translocation. These results provide insight into the molecular mechanism of translocation.

PMID:
22020300
DOI:
10.1038/nsmb.2140
[Indexed for MEDLINE]

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