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Nat Rev Microbiol. 2011 Oct 24;10(1):8-12. doi: 10.1038/nrmicro2671.

Nucleoid occlusion and bacterial cell division.

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Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle-upon-Tyne, NE2 4AX, UK.


The bacterial cell cycle requires the tight regulation and precise coordination of several sophisticated cellular processes. Prominent among them is the formation of the dividing wall or septum, which has to take place at the right time and place to ensure equality of the progeny and integrity of the genome. Nucleoid occlusion is a defence mechanism that prevents the chromosome from being bisected and broken by the division septum. It does so by preventing Z ring formation near the nucleoid, which also helps to determine the location of septation.

[Indexed for MEDLINE]

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