Format

Send to

Choose Destination
See comment in PubMed Commons below
Mech Ageing Dev. 2011 Nov-Dec;132(11-12):568-72. doi: 10.1016/j.mad.2011.10.003. Epub 2011 Oct 12.

Leukocyte telomere length and physical ability among Danish twins age 70+.

Author information

1
Danish Aging Research Center, University of Southern Denmark, JB Winslowsvej 9B, DK-5000 Odense C, Denmark. laila.bendix@slb.regionsyddanmark.dk

Abstract

Leukocyte telomere length (LTL) shortens with age and is potentially a biomarker of human aging. We examined the relation of LTL with physical ability and cognitive function in 548 same-sex twins from the Longitudinal Study of Aging Danish Twins. LTL was measured by Southern blots of the terminal restriction fragments (TRF). Physical ability was evaluated using a self reported scale of 11 questions, while cognitive function was scored by MMSE and a cognitive composite score sensitive to age-related decline. A random intercept model revealed a positive, significant association between LTL and physical ability. For every unit increase in physical ability score, LTL increased by 0.066 kb (p = 0.01), equal to approximately three years of age-dependent LTL shortening. A matched case-co-twin design showed that the group consisting of the twins from each pair with the longer LTL also displayed better physical ability (p < 0.01). Moreover, the intra-pair difference in LTL was associated with intra-pair difference in physical ability (p < 0.01), confirming the association. However, we found no association between cognitive function and LTL. The LTL-physical ability association in the elderly provides further support to the premise that LTL is an index of somatic fitness in the narrow context of human physical health.

PMID:
22019938
PMCID:
PMC3243774
DOI:
10.1016/j.mad.2011.10.003
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center