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Psychopharmacology (Berl). 1990;101(4):465-71.

Role of D-1 and D-2 receptor stimulation in sensitization to amphetamine-induced circling behavior and in expression and extinction of the Pavlovian conditioned response.

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Department of Pharmacology and Toxicology, Albany Medical College, NY 12208.


Circling behavior was measured in female rats treated with amphetamine (1.25 mg/kg d-amphetamine sulfate, IP) on 3 consecutive days. On days 4 and 5 saline was substituted for amphetamine. While the amphetamine-induced response was attenuated by both a D-1 (SCH 23390) and a D-2 (metoclopramide) antagonist. sensitization to amphetamine was attenuated by the D-1 antagonist only. In addition, expression of a placebo-like response observed on day 4 (characterized previously as a Pavlovian conditioned response) was attenuated by both the D-1 and D-2 antagonists without disrupting extinction of the response.

[Indexed for MEDLINE]

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