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Mol Microbiol. 1990 May;4(5):821-30.

The complete nucleotide sequence of the Pasteurella multocida toxin gene and evidence for a transcriptional repressor, TxaR.

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  • 1Genetic Engineering Group, Technical University of Denmark, Lyngby.

Abstract

The osteolytic toxin of Pasteurella multocida induces bone resorption in vivo and in vitro (Foged et al., 1988; Kimman et al., 1987). In this report the toxin-encoding toxA gene is sequenced, and the deduced primary structure of the toxin shows a protein of 1285 amino acids, containing a striking homology to a metal-binding motif. Evidence that expression of the toxA gene is repressed at a transcriptional level in Escherichia coli is presented. Repression could be abolished either by deletion of a region upstream of toxA, or by a putative frame-shift mutation in the same region. The repressor protein encoded within this region was efficient in trans, and was named TxaR.

PMID:
2201870
[PubMed - indexed for MEDLINE]
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