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Neuron. 2011 Oct 20;72(2):231-43. doi: 10.1016/j.neuron.2011.09.027.

How inhibition shapes cortical activity.

Author information

1
Center for Neural Circuits and Behavior, University of California San Diego, La Jolla, CA 92093-0634, USA. jisaacson@ucsd.edu

Abstract

Cortical processing reflects the interplay of synaptic excitation and synaptic inhibition. Rapidly accumulating evidence is highlighting the crucial role of inhibition in shaping spontaneous and sensory-evoked cortical activity and thus underscores how a better knowledge of inhibitory circuits is necessary for our understanding of cortical function. We discuss current views of how inhibition regulates the function of cortical neurons and point to a number of important open questions.

PMID:
22017986
PMCID:
PMC3236361
DOI:
10.1016/j.neuron.2011.09.027
[Indexed for MEDLINE]
Free PMC Article
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