Acute generalized exanthematous pustulosis due to oral use of blue dyes

Osman Sener; Ösman Kose; Özgür Kartal; Mukerrem Safali

doi:10.3904/kjim.2011.26.3.360

Acute generalized exanthematous pustulosis due to oral use of blue dyes

Korean J Intern Med. 2011 Sep;26(3):360-3. doi: 10.3904/kjim.2011.26.3.360. Epub 2011 Sep 13.

Authors

Osman Sener¹, Ösman Kose, Özgür Kartal, Mukerrem Safali

Affiliation

¹ Division of Allergy, Department of Internal Medicine, Gülhane Military Medical Academy and Medical School, Ankara, Turkey.

Abstract

Acute generalized exanthematous pustulosis is a rare severe pustular cutaneous adverse reaction characterized by a rapid clinical course with typical histological findings. It is accompanied by fever and acute eruption of non-follicular pustules overlying erythrodermic skin. The causative agents are most frequently antibacterial drugs. We present a patient with acute generalized exanthematous pustulosis caused by methylene blue and indigotin dyes.

Keywords: Drug eruptions; Indigofera; Methylene blue.

Publication types

Case Reports

MeSH terms

Acute Generalized Exanthematous Pustulosis / chemically induced*
Acute Generalized Exanthematous Pustulosis / drug therapy
Acute Generalized Exanthematous Pustulosis / pathology
Administration, Oral
Adrenal Cortex Hormones / therapeutic use
Aged
Biopsy
Coloring Agents / administration & dosage
Coloring Agents / adverse effects*
Humans
Indigo Carmine
Indoles / administration & dosage
Indoles / adverse effects*
Intradermal Tests
Male
Methylene Blue / administration & dosage
Methylene Blue / adverse effects*
Skin / drug effects*
Skin / pathology
Treatment Outcome

Substances

Adrenal Cortex Hormones
Coloring Agents
Indoles
Indigo Carmine
Methylene Blue