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Chest. 2012 Apr;141(4):886-894. doi: 10.1378/chest.11-0633. Epub 2011 Oct 20.

Role of CXCL13 in asthma: novel therapeutic target.

Author information

1
Unidad de Investigacion en Enfermedades Oncologicas, Hospital Infantil de Mexico, Federico Gomez, Mexico City, Mexico.
2
Unidad de Investigación Medica en Oncologia, CMN sXXI IMSS, Mexico City, Mexico.
3
Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition "Salvador Zubirán," Mexico City, Mexico.
4
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
5
Department of Allergy and Clinical Immunology, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico. Electronic address: lmteran@iner.gob.mx.

Abstract

BACKGROUND:

B cells play an important role in allergic asthma. However, the mechanisms by which these cells are activated in the airways remain poorly understood.

METHODS:

We used a mouse model of ovalbumin (OVA)-induced allergic inflammation to study CXCL13 and to investigate the concentration of this chemokine in the BAL fluid derived from asthmatic and normal control subjects.

RESULTS:

We found that OVA-challenged mice upregulate the CXCL13/CXCR5 axis, which is associated with several changes in their airways, including recruitment of B and CD4(+) cells, development of bronchial-associated lymphoid tissue, and airway inflammation. Treating sensitized mice with an anti-CXCL13 antibody reduced cell recruitment, bronchial-associated lymphoid tissue formation, and airways inflammation. Interestingly, measurements of CXCL13 using enzyme-linked immunosorbent assay showed that levels of this cytokine were significantly elevated in BAL fluid from subjects with asthma compared with control subjects (median, 162 [range, 120-296] vs 31 [range, 120-156] pg/mL; P = .005).

CONCLUSIONS:

All together, these findings suggest that CXCL13 is involved in the allergic airway inflammatory process, and targeting this chemokine may constitute a novel approach in asthma.

PMID:
22016489
DOI:
10.1378/chest.11-0633
[Indexed for MEDLINE]

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