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Nat Rev Mol Cell Biol. 2011 Oct 21;12(11):757-63. doi: 10.1038/nrm3214.

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival.

Author information

1
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Abstract

Caspase 8 can initiate apoptosis, but it also has non-apoptotic roles; for example, it is required for embryonic development and immune cell proliferation. Recent work has indicated that the requirement for caspase 8 in development and immune cell proliferation is defined by suppression of receptor-interacting protein kinase 3 (RIPK3), a kinase that triggers an alternative form of cell death called programmed necrosis. Interestingly, these recent findings can be reconciled with earlier work on the non-apoptotic roles of caspase 8.

PMID:
22016059
PMCID:
PMC3627210
DOI:
10.1038/nrm3214
[Indexed for MEDLINE]
Free PMC Article

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