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Pancreas. 2012 Jan;41(1):50-3. doi: 10.1097/MPA.0b013e3182247625.

Genes related to diabetes may be associated with pancreatic cancer in a population-based case-control study in Minnesota.

Author information

1
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA. prizm001@umn.edu

Abstract

OBJECTIVES:

Type 2 diabetes is associated with increased pancreatic cancer risk; however, the nature of this relationship is not clear. We examined the link between 10 diabetes-related single-nucleotide polymorphisms and pancreatic cancer in a case-control study conducted in 1994 to 1998.

METHODS:

Cases (n = 162) were ascertained from hospitals in the Twin Cities and Mayo Clinic, Minn. Controls (n = 540) from the general population were frequency matched by age, sex, and race. Unconditional logistic regression provided odds ratios of pancreatic cancer and 95% confidence intervals (95% CIs).

RESULTS:

In a multivariate-adjusted model, a significant association was observed only for rs780094 in the glucokinase regulator (GCKR) gene: odds ratios for pancreatic cancer were 1.00 for TT, 1.35 (95% CI, 0.71-2.58) for CT, and 2.14 (95% CI, 1.12-4.08) for CC genotypes (P trend = 0.01) and did not change after the adjustment for diabetes.

CONCLUSIONS:

This study provides the first evidence that GCKR rs780094, a single-nucleotide polymorphism related to diabetes, may be associated with pancreatic cancer risk. Although the results from this analysis are preliminary, there is a biologic plausibility for such an association.

PMID:
22015968
PMCID:
PMC3241825
DOI:
10.1097/MPA.0b013e3182247625
[Indexed for MEDLINE]
Free PMC Article
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