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Cancer Cell. 2011 Oct 18;20(4):423-5. doi: 10.1016/j.ccr.2011.10.006.

Resistance to EGFR-targeted therapy: a family affair.

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Department of Radiation Oncology, Vanderbilt University, Nashville, TN 37232-2279, USA.


The EGFR-directed antibody cetuximab has proven, albeit modest, clinical benefit as monotherapy in head and neck and colorectal cancers. In a recent study, Yonesaka et al. uncovered a new mechanism of cetuximab resistance mediated by increased ERBB2 signaling via amplification of ERBB2 or increased levels of the ERBB3/ERBB4 ligand heregulin.

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