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Dev Cell. 2011 Oct 18;21(4):604-6. doi: 10.1016/j.devcel.2011.10.001.

Long, saturated chains: tasty domains for kinases of insulin resistance.

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Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.


The mechanistic basis of how cells respond to increased fatty acids (FAs) is murky but potentially involves receptor-mediated activation or inhibition by different FA classes. Holzer et al. (2011) recently propose in Cell that expansion of intracellular membrane microdomains induced by saturated FA recruit and activate c-Src for JNK activation.

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