Format

Send to

Choose Destination
Br J Dermatol. 2012 Mar;166(3):505-10. doi: 10.1111/j.1365-2133.2011.10699.x. Epub 2012 Feb 6.

Vitamin D status in patients with chronic plaque psoriasis.

Author information

1
Department of Medicine, Section of Dermatology and Venereology, Section of Rheumatology III Division of Geriatrics, University of Verona, Verona, Italy. paolo.gisondi@univr.it

Abstract

BACKGROUND:

Vitamin D could have important immunomodulatory effects in psoriasis.

OBJECTIVES:

To measure 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and calcium serum levels in patients with psoriasis and the associations with some relevant clinical features.

METHODS:

A cross-sectional study was conducted over 1 year including 145 patients with chronic plaque psoriasis, 112 patients with rheumatoid arthritis (RA) and 141 healthy controls. 25(OH)D, PTH and calcium serum levels were measured in a centralized laboratory. Demography, comorbidities, disease severity and exposure time to sunlight (which was derived by questionnaire) were collected.

RESULTS:

The prevalence of vitamin D deficiency [25(OH)D levels <20ngmL(-1) ] in patients with psoriasis was 57·8% vs. 37·5% in patients with RA and 29·7% in healthy controls (P<0·001). In winter, the prevalence of vitamin D deficiency rose to 80·9% in patients with psoriasis, to 41·3% in those with RA and to 30·3% in healthy controls (P<0·001). Patients with psoriasis or psoriatic arthritis did not differ in 25(OH)D serum levels nor in the prevalence of vitamin D deficiency. In the logistic regression analysis, vitamin D deficiency was associated with psoriasis independently of age, sex, body mass index, calcium, PTH levels and season of blood sampling. A limitation is that the study design does not allow a causal or temporal relationship between vitamin D deficiency and psoriasis to be established.

CONCLUSIONS:

Vitamin D deficiency may be common in patients with psoriasis, especially in winter.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center