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Mol Biosyst. 2012 Jan;8(1):320-6. doi: 10.1039/c1mb05274h. Epub 2011 Oct 20.

Intrinsic protein disorder in human pathways.

Author information

1
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA. fongj@ncbi.nlm.nih.gov

Abstract

We analyze human-specific KEGG pathways trying to understand the functional role of intrinsic disorder in proteins. Pathways provide a comprehensive picture of biological processes and allow better understanding of a protein's function within the specific context of its surroundings. Our study pinpoints a few specific pathways significantly enriched in disorder-containing proteins and identifies the role of these proteins within the framework of pathway relationships. Three major categories of relations are shown to be significantly enriched in disordered proteins: gene expression, protein binding and to a lesser degree, protein phosphorylation. Finally we find that relations involving protein activation and to some extent inhibition are characterized by low disorder content.

PMID:
22012032
PMCID:
PMC3584708
DOI:
10.1039/c1mb05274h
[Indexed for MEDLINE]
Free PMC Article

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