Format

Send to

Choose Destination
IEEE Trans Inf Technol Biomed. 2012 Jan;16(1):166-75. doi: 10.1109/TITB.2011.2171701. Epub 2011 Oct 17.

Secure management of biomedical data with cryptographic hardware.

Author information

1
Department of Computer Science, University of Texas at Dallas, Richardson, TX 75083, USA. canim@utdallas.edu

Abstract

The biomedical community is increasingly migrating toward research endeavors that are dependent on large quantities of genomic and clinical data. At the same time, various regulations require that such data be shared beyond the initial collecting organization (e.g., an academic medical center). It is of critical importance to ensure that when such data are shared, as well as managed, it is done so in a manner that upholds the privacy of the corresponding individuals and the overall security of the system. In general, organizations have attempted to achieve these goals through deidentification methods that remove explicitly, and potentially, identifying features (e.g., names, dates, and geocodes). However, a growing number of studies demonstrate that deidentified data can be reidentified to named individuals using simple automated methods. As an alternative, it was shown that biomedical data could be shared, managed, and analyzed through practical cryptographic protocols without revealing the contents of any particular record. Yet, such protocols required the inclusion of multiple third parties, which may not always be feasible in the context of trust or bandwidth constraints. Thus, in this paper, we introduce a framework that removes the need for multiple third parties by collocating services to store and to process sensitive biomedical data through the integration of cryptographic hardware. Within this framework, we define a secure protocol to process genomic data and perform a series of experiments to demonstrate that such an approach can be run in an efficient manner for typical biomedical investigations.

PMID:
22010157
PMCID:
PMC4156282
DOI:
10.1109/TITB.2011.2171701
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for IEEE Engineering in Medicine and Biology Society Icon for PubMed Central
Loading ...
Support Center