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J Antibiot (Tokyo). 2011 Dec;64(12):775-80. doi: 10.1038/ja.2011.96. Epub 2011 Oct 19.

Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38.

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Institut für Chemie, Technische Universität Berlin, Berlin, Germany.


Three new 22-membered macrolactone antibiotics, atacamycins A-C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells.

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