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Biochemistry. 2011 Nov 15;50(45):9681-3. doi: 10.1021/bi201223u. Epub 2011 Oct 20.

Unravelling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR.

Author information

1
Department of Pharmacy, University of Patras, GR-26504 Patras, Greece.

Abstract

Pentameric ligand-gated ion channels (pLGICs) of the Cys loop family are transmembrane glycoproteins implicated in a variety of biological functions. Here, we present a solution NMR study of the extracellular domain of a prokaryotic pLGIC homologue from the bacterium Gloeobacter violaceus that is found to be a monomer in solution.

PMID:
22007668
DOI:
10.1021/bi201223u
[Indexed for MEDLINE]

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