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J Biomed Biotechnol. 2011;2011:567305. doi: 10.1155/2011/567305. Epub 2011 Oct 11.

E-cadherin/β-catenin complex and the epithelial barrier.

Author information

1
Centre for Transplantation and Renal Research, Westmead Millennium Institute, The University of Sydney, NSW 2145, Australia.

Abstract

E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal transition. These associations provide insights into the complexity that is likely responsible for the fibrosis/tumor suppressive action of E-cadherin/β-catenin.

PMID:
22007144
PMCID:
PMC3191826
DOI:
10.1155/2011/567305
[Indexed for MEDLINE]
Free PMC Article

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