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Chem Biodivers. 2011 Oct;8(10):1901-7. doi: 10.1002/cbdv.201000237.

Novel terpenoids from Calocedrus macrolepis var. formosana.

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1
Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.

Abstract

Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C(20)-C(10) skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC(50) value of 9.0±0.1 μM.

PMID:
22006718
DOI:
10.1002/cbdv.201000237
[Indexed for MEDLINE]
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