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Antioxid Redox Signal. 2012 Mar 1;16(5):452-7. doi: 10.1089/ars.2011.4343. Epub 2011 Dec 16.

Do cysteine residues regulate transient receptor potential canonical type 6 channel protein expression?

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Department of Medicine, Division of Nephrology, Charité Campus Benjamin Franklin, Berlin, Germany.


The regulation of calcium influx through transient receptor potential canonical type 6 (TRPC6) channel is mandatory for the activity of human monocytes. We submit the first evidence that cysteine residues of homocysteine (HC) or acetylcysteine (ACC) affect TRPC6 expression in human monocytes. We observed that patients with chronic renal failure had significantly elevated HC levels and TRPC6 mRNA expression levels in monocytes compared with control subjects. We further observed that administration of HC or ACC significantly increased TRPC6 channel protein expression compared with control conditions. We, therefore, hypothesize that cysteine residues increase TRPC6 channel protein expression in humans.

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