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Viral Immunol. 2011 Oct;24(5):409-13. doi: 10.1089/vim.2011.0028.

Efficient neutralization of primary isolates by the plasma from HIV-1 infected Indian children.

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1
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.

Abstract

We tested the plasma of 51 HIV-1-infected children (23 naïve and 28 ART treated) for neutralization against five primary isolates (PIs) generated from adult Indian HIV-1-infected patients. The plasma exhibited neutralization potential with significantly higher neutralizing antibody titers in ART-treated children than naïve children against three out of five PIs (p<0.0001). Further, in treated children, neutralizing antibody titers were higher in those children with suppressed viremia (<1000 RNA copies/mL) than non-suppressors against two of the three PIs. We report here for the first time the neutralization potential of the plasma of HIV-1-infected Indian children.

PMID:
22004138
DOI:
10.1089/vim.2011.0028
[Indexed for MEDLINE]
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