Format

Send to

Choose Destination
See comment in PubMed Commons below
Semin Cell Dev Biol. 2011 Dec;22(9):968-74. doi: 10.1016/j.semcdb.2011.09.017. Epub 2011 Oct 4.

Regulation of cell migration by dynamic microtubules.

Author information

1
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 3160 MRBIII, 465 21st Avenue South, Nashville, TN 37232-8240, USA. Irina.Kaverina@Vanderbilt.Edu

Abstract

Microtubules define the architecture and internal organization of cells by positioning organelles and activities, as well as by supporting cell shape and mechanics. One of the major functions of microtubules is the control of polarized cell motility. In order to support the asymmetry of polarized cells, microtubules have to be organized asymmetrically themselves. Asymmetry in microtubule distribution and stability is regulated by multiple molecular factors, most of which are microtubule-associated proteins that locally control microtubule nucleation and dynamics. At the same time, the dynamic state of microtubules is key to the regulatory mechanisms by which microtubules regulate cell polarity, modulate cell adhesion and control force-production by the actin cytoskeleton. Here, we propose that even small alterations in microtubule dynamics can influence cell migration via several different microtubule-dependent pathways. We discuss regulatory factors, potential feedback mechanisms due to functional microtubule-actin crosstalk and implications for cancer cell motility.

PMID:
22001384
PMCID:
PMC3256984
DOI:
10.1016/j.semcdb.2011.09.017
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center