Format

Send to

Choose Destination
See comment in PubMed Commons below
Semin Cell Dev Biol. 2011 Dec;22(9):916-26. doi: 10.1016/j.semcdb.2011.09.014. Epub 2011 Oct 5.

What tubulin drugs tell us about microtubule structure and dynamics.

Author information

1
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. laa@mrc-lmb.cam.ac.uk

Abstract

A wide range of small molecules, including alkaloids, macrolides and peptides, bind to tubulin and disturb microtubule assembly dynamics. Some agents inhibit assembly, others inhibit disassembly. The binding sites of drugs that stabilize microtubules are discussed in relation to the properties of microtubule associated proteins. The activities of assembly inhibitors are discussed in relation to different nucleotide states of tubulin family protein structures.

PMID:
22001382
DOI:
10.1016/j.semcdb.2011.09.014
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center