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Semin Cell Dev Biol. 2011 Dec;22(9):927-34. doi: 10.1016/j.semcdb.2011.09.021. Epub 2011 Oct 5.

Regulation of microtubule dynamics by kinesins.

Author information

1
Centre for Mechanochemical Cell Biology, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom. d.drummond@mechanochemistry.org

Abstract

The simple mechanistic and functional division of the kinesin family into either active translocators or non-motile microtubule depolymerases was initially appropriate but is now proving increasingly unhelpful, given evidence that several translocase kinesins can affect microtubule dynamics, whilst non-translocase kinesins can promote microtubule assembly and depolymerisation. Such multi-role kinesins act either directly on microtubule dynamics, by interaction with microtubules and tubulin, or indirectly, through the transport of other factors along the lattice to the microtubule tip. Here I review recent progress on the mechanisms and roles of these translocase kinesins.

PMID:
22001250
DOI:
10.1016/j.semcdb.2011.09.021
[Indexed for MEDLINE]

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