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Exp Neurol. 2012 Jan;233(1):79-86. doi: 10.1016/j.expneurol.2011.09.035. Epub 2011 Oct 6.

Stress, depression and Parkinson's disease.

Author information

1
Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

Abstract

In this review, we focus on the relationship among Parkinson's disease (PD), stress and depression. Parkinson's disease patients have a high risk of developing depression, and it is possible that stress contributes to the development of both pathologies. Stress dysfunction may have a role in the etiology of preclinical non-motor symptoms of PD (such as depression) and, later in the course of the disease, may worsen motor symptoms. However, relatively few studies have examined stress or depression and the injured nigrostriatal system. This review discusses the effects of stress on neurodegeneration and depression, and their association with the symptoms and progression of PD.

PMID:
22001159
PMCID:
PMC3268878
DOI:
10.1016/j.expneurol.2011.09.035
[Indexed for MEDLINE]
Free PMC Article

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