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Curr Opin Pharmacol. 2011 Dec;11(6):575-81. doi: 10.1016/j.coph.2011.09.008. Epub 2011 Oct 13.

Achieving translation in models of visceral pain.

Author information

1
Wingate Institute of Neurogastroenterology, Blizard Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AJ, United Kingdom. d.bulmer@qmul.ac.uk

Abstract

The failure of drugs to modify pain end points in clinical trials for irritable bowel syndrome (IBS) highlights the knowledge gap that exists in the translation of efficacy in animal models of visceral pain into the clinic. Recent progress has been made towards improving the translation of visceral pain, particularly with regard to the activation of the sensory nerves which relay pain from the gut to the brain. This review will focus on studies which have identified the presence of an altered gastrointestinal and immune environment in IBS patients. The development of human gastrointestinal visceral afferent recordings has allowed direct comparison between sensory nerve studies in animals and human, as well as important advances in our understanding of the ion channels that underpin the changes in sensory nerve excitability.

PMID:
22000605
DOI:
10.1016/j.coph.2011.09.008
[Indexed for MEDLINE]

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