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J Neuroimmunol. 2011 Oct 28;239(1-2):44-52. doi: 10.1016/j.jneuroim.2011.08.006. Epub 2011 Oct 13.

Social disruption induced priming of CNS inflammatory response to Theiler's virus is dependent upon stress induced IL-6 release.

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1
Dept. of Psychology, College of Liberal Arts, Texas A&M University, United States.

Abstract

Chronic social disruption stress (SDR) exacerbates acute and chronic phase Theiler's murine encephalomyelitis virus (TMEV) infection, a mouse model of multiple sclerosis. However, the precise mechanism by which this occurs remains unknown. The present study suggests that SDR exacerbates TMEV disease course by priming virus-induced neuroinflammation. It was demonstrated that IL-1β mRNA expression increases following acute SDR; however, IL-6 mRNA expression, but not IL-1β, is upregulated in response to chronic SDR. Furthermore, this study demonstrated SDR prior to infection increases infection related central IL-6 and IL-1β mRNA expression, and administration of IL-6 neutralizing antibody during SDR reverses this increase in neuroinflammation.

PMID:
22000153
PMCID:
PMC3205213
DOI:
10.1016/j.jneuroim.2011.08.006
[Indexed for MEDLINE]
Free PMC Article
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