Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2011 Oct 14;147(2):275-92. doi: 10.1016/j.cell.2011.09.024.

Tumor metastasis: molecular insights and evolving paradigms.

Author information

1
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. scott_valastyan@hms.harvard.edu

Abstract

Metastases represent the end products of a multistep cell-biological process termed the invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically distant organ sites and their subsequent adaptation to foreign tissue microenvironments. Each of these events is driven by the acquisition of genetic and/or epigenetic alterations within tumor cells and the co-option of nonneoplastic stromal cells, which together endow incipient metastatic cells with traits needed to generate macroscopic metastases. Recent advances provide provocative insights into these cell-biological and molecular changes, which have implications regarding the steps of the invasion-metastasis cascade that appear amenable to therapeutic targeting.

PMID:
22000009
PMCID:
PMC3261217
DOI:
10.1016/j.cell.2011.09.024
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center