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Cell. 2011 Oct 14;147(2):271-4. doi: 10.1016/j.cell.2011.09.010.

Hiding in plain sight: how HIV evades innate immune responses.

Author information

1
Institut Curie-INSERM U, Paris, France. nicolas.manel@curie.fr

Abstract

Two groups have identified SAMHD1, a protein encoded by an Aicardi-Goutières Syndrome susceptibility gene, as the factor that restricts infection of macrophages and dendritic cells with HIV-1. Here we discuss implications of this discovery for induction of antiviral protective immunity.

PMID:
22000008
PMCID:
PMC3624893
DOI:
10.1016/j.cell.2011.09.010
[Indexed for MEDLINE]
Free PMC Article

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