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J Nat Prod. 2011 Oct 28;74(10):2313-7. doi: 10.1021/np200610t. Epub 2011 Oct 14.

Cannabinomimetic lipid from a marine cyanobacterium.

Author information

1
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography , and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.

Abstract

NMR-guided fractionation of two independent collections of the marine cyanobacteria Lyngbya majuscula obtained from Papua New Guinea and Oscillatoria sp. collected in Panama led to the isolation of the new lipids serinolamide A (3) and propenediester (4). Their structures were determined by NMR and MS data analysis. Serinolamide A (3) exhibited a moderate agonist effect and selectivity for the CB1 cannabinoid receptor (Ki=1.3 μM, >5-fold) and represents the newest addition to the known cannabinomimetic natural products of marine origin.

PMID:
21999614
PMCID:
PMC3325759
DOI:
10.1021/np200610t
[Indexed for MEDLINE]
Free PMC Article

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