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Stroke. 2012 Jan;43(1):262-4. doi: 10.1161/STROKEAHA.111.635664. Epub 2011 Oct 13.

Mortality of cerebral venous-sinus thrombosis in a large national sample.

Author information

1
Souers Stroke Institute, Department of Neurology, St Louis University, 1438 S Grand Boulevard, St Louis, MO 63104, USA.

Abstract

BACKGROUND AND PURPOSE:

The purpose of this study was to evaluate the mortality rates associated with cerebral venous-sinus thrombosis in a large national sample.

METHODS:

A cohort of patients with cerebral venous-sinus thrombosis was identified from the National Inpatient Sample database for the years 2000 to 2007. According to the International Classification of Diseases, 9th Revision, Clinical Modification codes, cerebral venous-sinus thrombosis is categorized into pyogenic and nonpyogenic groups. Multivariate logistic regression analysis was used to assess covariates associated with hospital mortality.

RESULTS:

Among 3488 patients, the overall mortality rate was 4.39%, which was nonsignificantly higher among the pyogenic group (4.55% versus 3.52%; OR, 0.76; 95% CI, 0.47-1.23). In the pyogenic cerebral venous-sinus thrombosis group, hematologic disorders were the most frequent predisposing condition (16.2%); whereas systemic malignancy followed by hematologic disorders were most common in the nonpyogenic group (14.08% and 10.04%, respectively). Predictors of mortality included age, intracerebral hemorrhage as well as the predisposing conditions of hematologic disorders, systemic malignancy, and central nervous system infection.

CONCLUSIONS:

Compared with arterial stroke, CVST harbors a relatively low mortality rate. Death is determined by age, the presence of intracerebral hemorrhage, and certain predisposing conditions.

PMID:
21998058
DOI:
10.1161/STROKEAHA.111.635664
[Indexed for MEDLINE]

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