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Opt Express. 2011 Oct 10;19(21):20097-102. doi: 10.1364/OE.19.020097.

Real-time handheld optical-resolution photoacoustic microscopy.

Author information

1
Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta T6G 2V, Canada.

Abstract

In this paper a new generation of optical-resolution photoacoustic microscopy (OR-PAM) with a wide range of potential clinical applications is demonstrated. Using fast scanning mirrors, an image guide with 30,000 fiber pixels, a refocusing lens and a unique probe we managed to reduce the footprint of an OR-PAM system from a stationary table-top system to a portable, 4 cm by 6 cm, probe weighing ~500 g tethered to a scanning unit. The phantom studies show that the handheld optical-resolution photoacoustic microscope is able to image with ~7 μm resolution. For in vivo studies images of the microvasculature in a Swiss Webster mouse ear are shown. The compact, flexible nature of the proposed design and the small footprint of the apparatus increase the usability of OR-PAM for potential clinical applications such as in dermatology.

PMID:
21997020
DOI:
10.1364/OE.19.020097
[Indexed for MEDLINE]

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